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What is The Plant MAPK Network Resource?

This is a general repository of MAPK, MKK sequences and orthologues in the plant kingdom. Orthologues were inferred using the InParanoid and Plaza orthologue identifier programs. This site also contains pointers to published evidence for constructing MAPK networks in Arabidopsis Yeast and Human, including high throughput and targeted experiments. The base dataset included here appeared in the paper by Dóczi, Ökrész, Romero, Paccanaro and Bögre (see reference). This dataset is continuously being refined and it is maintained by the staff at PaccanaroLab. If you wish to add a new entry or point out a missing entry, contact Dr. Alberto Paccanaro at: alberto - at - cs.rhul.ac.uk or Prof. László Bögre at: l.bogre - at - rhul.ac.uk

The dataset

MAPK and MEK sequences in plants

Orthologs of Arabidopsis MAPKs and MKKs as suggested by ortholog identifier programs:

References for MKK-MPK interactions

MAPK and MEK sequences in plants

MAPK and MKK sequences in green plants and in Naegleria

 

MAPK: TDY

MAPK: TEY

ERK8-like

MHK

MKK

Naegleria gruberi

0

1

1

2

2

XP_002672114

XP_002675531

XP_002675576
XP_002679174

XP_002675852
XP_002678931

Chlamydomonas reinhardtii

2

3

1

2

2

XP_001703601
XP_001694300

XP_001690852
XP_001690850
XP_001700291

XP_001699095

XP_001697865
XP_001693587

XP_001696437
XP_001693665

Volvox carteri

2

2

1

2

2

XP_002954138
XP_002954367

XP_002955338
XP_002948304

XP_002951120

XP_002948753
XP_002949787

XP_002947566
XP_002958286

Micromonas sp.

1

2

1

2

2

 

XP_002503335

XP_002503699
XP_002501054

XP_002507666

XP_002502211
XP_002505908

XP_002504085
XP_002506404

Ostreococcus tauri

1

2

0

0

1

 

XP_003080614

XP_003081390
XP_003083155

 

 

XP_003078923

Ostreococcus lucimarinus

1

2

0

0

1

 

XP_001419059

XP_001419851
XP_001419478

 

 

XP_001417318

Physcomitrella patens

2

6

1

5

7

 

XP_001765894
XP_001766825

XP_001771474
XP_001776547
XP_001772376
XP_001763232
XP_001768064
XP_001757752

XP_001766838

XP_001758774
XP_001757612
XP_001774238
XP_001785524
XP_001771484

XP_001755215
XP_001769374
XP_001761737
XP_001758355
XP_001768791
XP_001772493
XP_001767359

Selaginella moellendorffii

4

4

2

4

5

 

XP_002984293
XP_002966854
XP_002972463
XP_002961155

XP_002967096
XP_002960915
XP_002976409
XP_002976336

XP_002977037
XP_002964959

XP_002987235
XP_002976402
XP_002976848
XP_002961712

XP_002968717
XP_002988344
XP_002991584
XP_002960466
XP_002967256

Populus trichocarpa

9

13

0

5

11

 

XP_002322093
XP_002331327
XP_002300882
XP_002314806
XP_002314421
XP_002312737
XP_002307544
XP_002317882
XP_002298926

XP_002298015
XP_002320818
XP_002304516
XP_002298450
XP_002334994
XP_002323707
XP_002314017
XP_002302599
XP_002310398
XP_002310268
XP_002327783
XP_002306886
XP_002302017

 

XP_002301806
XP_002303962
XP_002304373
XP_002323157
XP_002299172

XP_002315388
XP_002310949
XP_002324775
XP_002326539
XP_002329737
XP_002330495
XP_002318307
XP_002311752
XP_002308276
XP_002335442
XP_002298538

Oryza sativa

9

6

0

3

7

 

NP_001043794
NP_001056404
NP_001067677
NP_001043694
NP_001056342
NP_001043642
NP_001058530
NP_001057613
NP_001045815

NP_001061028
NP_001065156
NP_001056846
NP_001049770
NP_001058471
NP_001045889

 

NP_001056617
NP_001047841
NP_001051886

NP_001057028
NP_001048341
NP_001049430
AAL58223
EEE65707
NP_001056806
NP_001043164

Arabidopsis thaliana

8

12

0

3

10

 

MAPK8 AT1G18150
MAPK9 AT3G18040
MAPK15 AT1G73670
MAPK1 AT5G19010
MAPK17 AT2G01450
MAPK18 AT1G53510
MAPK19 AT3G14720
MAPK20 AT2G42880

MAPK1 AT1G10210
MAPK2 AT1G59580
MAPK7 AT2G18170
MAPK14 AT4G36450
MAPK5 AT4G11330
MAPK11 AT1G01560
MAPK13 AT1G07880
MAPK12 AT2G46070
MAPK4 AT4G01370
MAPK6 AT2G43790
MAPK3 AT3G45640
MAPK10 AT3G59790

 

MAPK21 AT4G13020
MAPK22 AT4g19110
MAPK23 AT5g45430

MKK1 AT4G26070
MKK2 AT4G29810
MKK3 AT5G40440
MKK4 AT1G51660
MKK5 AT3G21220
MKK6 AT5G56580
MKK7 AT1G18350
MKK8 AT3G06230
MKK9 AT1G73500
MKK10 AT1G32320


Top Orthologs of Arabidopsis MAPKs and MKKs as suggested by ortholog identifier programs

 

Arabidopsis thaliana

Selaginella moellendorffii

Physcomitrella patens

Chlamydomonas reinhardtii

Volvox carteri

Ostreococcus lucimarinus

Ostreococcus tauri

Micromonas sp. RCC299

Naegleria gruberi

MAPK

TDY

 

 

 

 

 

 

 

 

Group D

MPK8 AT1G18150

 

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

 

 

MPK9 AT3G18040

 

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

XP_002672114_nag

 

MPK15 AT1G73670

 

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

 

 

MPK16 AT5G19010

XP_002961155_sel

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

XP_002672114_nag

 

 

XP_002966854_sel

 

 

 

 

 

 

 

 

MPK17 AT2G01450

 

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

 

 

MPK18 AT1G53510

 

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

 

 

MPK19 AT3G14720

 

 

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

XP_002672114_nag

 

MPK20 AT2G42880

 

XP_001765894_phy

XP_001694300_chl

XP_002954367_vol

XP_001419059_olu

XP_003080614_ota

XP_002503335_mic

XP_002672114_nag

 

 

 

XP_001766825_phy

 

 

 

 

 

 

 

TEY

 

 

 

 

 

 

 

 

Group C

MPK1 AT1G10210

XP_002967096_sel

XP_001776547_phy

 

 

 

 

 

XP_002672114_nag

 

 

XP_002960915_sel

XP_001771474_phy

 

 

 

 

 

 

 

 

XP_002976409_sel

 

 

 

 

 

 

 

 

MPK2 AT1G59580

XP_002967096_sel

XP_001776547_phy

 

 

 

 

 

XP_002672114_nag

 

 

XP_002960915_sel

XP_001771474_phy

 

 

 

 

 

 

 

 

XP_002976409_sel

 

 

 

 

 

 

 

 

MPK7 AT2G18170

XP_002967096_sel

XP_001776547_phy

 

 

 

 

 

XP_002672114_nag

 

 

XP_002960915_sel

XP_001771474_phy

 

 

 

 

 

 

 

 

XP_002976409_sel

 

 

 

 

 

 

 

 

MPK14 AT4G36450

XP_002967096_sel

XP_001776547_phy

 

 

 

 

 

XP_002672114_nag

 

 

XP_002960915_sel

XP_001771474_phy

 

 

 

 

 

 

 

 

XP_002976409_sel

 

 

 

 

 

 

 

Group B

MPK5 AT4G11330

 

 

 

 

 

 

 

XP_002672114_nag

 

MPK11 AT1G01560

 

 

 

 

 

 

 

 

 

MPK13 AT1G07880

 

 

XP_001700291_chl

XP_002955338_vol

XP_001419851_olu

XP_003081390_ota

XP_002503699_mic

 

 

MPK12 AT2G46070

XP_002976336_sel

 

XP_001700291_chl

XP_002955338_vol

XP_001419851_olu

XP_003081390_ota

XP_002501054_mic

 

 

MPK4 AT4G01370

XP_002976336_sel

XP_001763232_phy

XP_001700291_chl

XP_002955338_vol

XP_001419851_olu

XP_003081390_ota

XP_002501054_mic

XP_002672114_nag

Group A

MPK6 AT2G43790

 

 

XP_001700291_chl

XP_002955338_vol

XP_001419851_olu

XP_003081390_ota

XP_002503699_mic

XP_002672114_nag

 

MPK3 AT3G45640

 

 

XP_001700291_chl

XP_002955338_vol

XP_001419851_olu

XP_003081390_ota

XP_002501054_mic

XP_002672114_nag

 

MPK10 AT3G59790

 

 

XP_001700291_chl

 

XP_001419851_olu

XP_003081390_ota

XP_002503699_mic

XP_002672114_nag

 

 

 

 

 

 

 

 

 

 

MHK

MPK21AT4G13020

 

 

 

 

 

 

 

 

 

MPK22 At4G19110

XP_002987235_sel

XP_001757612_phy

XP_001697865_chl

XP_002949787_vol

 

 

XP_002505908_mic

XP_002675576_nag

 

 

 

XP_001785524_phy

 

 

 

 

 

 

 

 

 

XP_001774238_phy

 

 

 

 

 

 

 

MPK23 At5G45430

XP_002987235_sel

XP_001757612_phy

XP_001697865_chl

XP_002949787_vol

 

 

XP_002505908_mic

XP_002675576_nag

 

 

 

XP_001785524_phy

 

 

 

 

 

 

 

 

 

XP_001774238_phy

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



Top Orthologs of Arabidopsis MAPKs as determined by the PLAZA plant comparative genomics platform 

 

Arabidopsis thaliana

Selaginella moellendorffii

Physcomitrella patens

Chlamydomonas reinhardtii

Volvox carteri

Ostreococcus lucimarinus

Ostreococcus tauri

Micromonas sp. RCC299

Naegleria gruberi

Group D

8,9,15,16,17,18,19,20

XP_002966854

XP_001765894

XP_001694300

XP_002954367

XP_001419059

XP_003080614

XP_002503335

 

 

 

XP_002984293

XP_001766825

 

 

 

 

 

 

Group C

1,2,7,14

XP_002960915

XP_001771474

XP_001690850

 

 

 

 

 

Group B

4,11,12

XP_002976336

XP_001763232

 

 

 

 

XP_002503699

 

Group A

6

 

 

XP_001700291

XP_002955338

XP_001419851

XP_003081390

 

 

 

3,5,10,13 no

ortholog

 

 

 

 

 

 

 

 

MHK

21.22

XP_002976402

XP_001757612

XP_001697865

XP_002949787

 

 

XP_002505908

 

 

 

 

XP_001774238

 

 

 

 

 

 

 

 

 

XP_001785524

 

 

 

 

 

 

 

23 no ortholog

 

 

 

 

 

 

 

 



Top

Orthologs of Arabidopsis MKKs as determined by the PLAZA plant comparative genomics platform  

 

Arabidopsis thaliana

Selaginella moellendorffii

Physcomitrella patens

Chlamydomonas reinhardtii

Volvox carteri

Ostreococcus lucimarinus

Ostreococcus tauri

Micromonas sp. RCC299

Naegleria gruberi

Group A

MKK6 AT5G56580

XP_002968717

XP_001758355

XP_001693665

XP_002947566

 

 

XP_002504085

 

 

 

 

XP_001761737

 

 

 

 

 

 

 

 

 

XP_001768791

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group B

MKK3 AT5G40440

XP_002960466

XP_001767359

XP_001696437

XP_002958286

 

 

XP_002506404

 

 

 

 

XP_001772493

 

 

 

 

 

 

Group D

MKK9 AT1G73500

XP_002991584

XP_001755215

 

 

 

 

 

 

 

 

 

XP_001769374

 

 

 

 

 

 

 

1,2,4,5,7,8,10 no ortholog

 

 

 

 

 

 

 

 



Top

Orthologs of Arabidopsis MKKs as determined by the InParanoid ortholog identifier program 

 

Arabidopsis thaliana

Selaginella moellendorffii

Physcomitrella patens

Chlamydomonas reinhardtii

Volvox carteri

Ostreococcus lucimarinus

Ostreococcus tauri

Micromonas sp. RCC299

Naegleria gruberi

Group A

MKK1

 

 

 

XP_002947566_vol

XP_001417318_olu

XP_003078923_ota

XP_002504085_mic

XP_002675852_nag

 

MKK2

 

 

 

XP_002947566_vol

XP_001417318_olu

XP_003078923_ota

XP_002504085_mic

XP_002675852_nag

 

MKK6

XP_002988344_sel

XP_001758355_phy

 

XP_002947566_vol

XP_001417318_olu

XP_003078923_ota

XP_002504085_mic

XP_002675852_nag

 

 

 

XP_001768791_phy

 

 

 

 

 

 

Group B

MKK3

XP_002960466_sel

XP_001767359_phy

XP_001696437_chl

 

XP_001417318_olu

XP_003078923_ota

 

XP_002675852_nag

 

 

 

XP_001772493_phy

 

 

 

 

 

 

Group C

MKK4

 

 

 

 

 

 

 

 

 

MKK5

 

 

 

 

 

 

 

 

Group D

MKK7

XP_002991584_sel

XP_001769374_phy

 

 

 

 

 

 

 

 

XP_002968717_sel

XP_001755215_phy

 

 

 

 

 

 

 

MKK8

XP_002991584_sel

XP_001769374_phy

 

 

 

 

 

 

 

 

XP_002968717_sel

XP_001755215_phy

 

 

 

 

 

 

 

MKK9

XP_002991584_sel

XP_001769374_phy

 

 

 

 

 

 

 

 

XP_002968717_sel

XP_001755215_phy

 

 

 

 

 

 

 

MKK10

 

 

 

 

 

 

 

 



Top

Yeast

Interaction

References (low throughput)

References (high throughput)

MKK1 → SLT2

PUBMED:9493378, PUBMED:8596433, PUBMED:17711850, PUBMED:8596433, PUBMED:22006927

PUBMED:20489023, PUBMED:21118957

MKK2 → SLT2

PUBMED:11805837, PUBMED:8596433, PUBMED:17711850, PUBMED:8757399

PUBMED:20489023, PUBMED:11805837

PBS2 → HOG1

PUBMED:9180081, PUBMED:18212044, PUBMED:21698101

PUBMED:21118957

STE7 → FUS3

PUBMED:19303851, PUBMED:8668180, PUBMED:15456892, PUBMED:8384702

PUBMED:20489023, PUBMED:21118957

STE7 → HOG1

PUBMED:20489023

PUBMED:20489023

STE7 → KSS1

PUBMED: 19303851, PUBMED:11805837, PUBMED:8668180

PUBMED:20489023

Top

Human

Interactions

References (low throughput)

References (high throughput)

MEK1 → MAPK1

PUBMED:10757792 PUBMED:11134045 PUBMED:11226259 PUBMED:11266467 PUBMED:11279118 PUBMED:11352917 PUBMED:11741894 PUBMED:11823456 PUBMED:12697810 PUBMED:16887817 PUBMED:17255949 PUBMED:17367534 PUBMED:8670897

 

MEK1 → MAPK3

PUBMED:10748187 PUBMED:11134045 PUBMED:17367534 PUBMED:19197339 PUBMED:8226933 PUBMED:8626767 PUBMED:9006895 PUBMED:9733512

 

MEK2 → MAPK1

PUBMED:11823456

 

MEK2 → MAPK3

PUBMED:8626767 PUBMED:8226933 PUBMED:9006895

 

MEK3 → MAPK14

PUBMED:17255949 PUBMED:11279118

 

MEK3 → MAPK3

PUBMED:8226933

 

MEK4 → MAPK8

PUBMED:11823456 PUBMED:10713157 PUBMED:11279118

 

MEK4 → MAPK9

 

PUBMED:21900206

MEK5 → MAPK7

PUBMED:7759517

 

MEK6 → MAPK14

PUBMED:17255949 PUBMED:12697810 PUBMED:8622669 PUBMED:11279118

 

MEK7 → MAPK8

PUBMED:10713157 PUBMED:9207092

 

MEK7 → MAPK14

PUBMED:9207092

 

Top

Arabidopsis

Interactions

References (low throughput)

References (high throughput)

MKK1 → MPK4

PUBMED:18982020; PUBMED:9878570; PUBMED:9804171; PUBMED:19513235; PUBMED:15225555

 

MKK1 → MPK11

PUBMED:19513235

 

MKK1 → MPK12

PUBMED:19000167

 

MKK1 → MPK3

PUBMED:17059410

 

MKK1 → MPK6

PUBMED:17059410

 

MKK2 → MPK4

PUBMED:18982020; PUBMED:9878570; PUBMED:19513235; PUBMED:15225555

 

MKK2 → MPK5

PUBMED:15225555

 

MKK2 → MPK6

PUBMED:19513235; PUBMED:15225555

PUBMED:21798944

MKK2 → MPK10

PUBMED:19513235

 

MKK2 → MPK11

PUBMED:19513235

 

MKK2 → MPK13

PUBMED:19513235

 

MKK3 → MPK1

PUBMED:19513235

 

MKK3 → MPK2

PUBMED:19513235

 

MKK3 → MPK7

PUBMED:19513235

 

MKK3 → MPK14

PUBMED:19513235

 

MKK3 → MPK6

PUBMED:21419340

 

MKK3 → MPK8

PUBMED:17369371

 

MKK4 → MPK3

PUBMED:19513235

PUBMED:21798944

MKK4 → MPK6

PUBMED:19513235

PUBMED:21798944

MKK5 → MPK3

Doczi unpublished

 

MKK5 → MPK6

PUBMED:19513235

 

MKK6 → MPK4

PUBMED:21575092; PUBMED:20802223; PUBMED:19513235

 

MKK6 → MPK6

PUBMED:21575092; PUBMED:19513235

 

MKK6 → MPK11

PUBMED:21575092; PUBMED:19513235

 

MKK6 → MPK12

PUBMED:20802223; PUBMED:19000167

 

MKK6 → MPK13

PUBMED:21575092; PUBMED:20802223; PUBMED:19513235

 

MKK7 → MPK2

PUBMED:19513235

 

MKK7 → MPK12

PUBMED:19000167

 

MKK7 → MPK15

PUBMED:19513235

 

MKK9 → MPK6

PUBMED:19513235

 

MKK9 → MPK10

PUBMED:19513235

 

MKK9 → MPK12

PUBMED:19000167

 

MKK9 → MPK17

PUBMED:19513235

 

MKK9 → MPK20

PUBMED:19513235

 

MKK10 → MPK17

PUBMED:19513235